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在孕产妇糖尿病中炎症和胎盘的相互作用:对霍夫尔细胞表达模式的洞察

Zdenek Tauber¹, Adela Burianova¹, Katerina Koubova¹

¹Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czechia.

Frontiers in immunology

|April 9, 2024

概括

孕产妇糖尿病,包括1型糖尿病 (T1DM) 和妊娠糖尿病 (GDM),会改变胎盘的霍夫尔细胞 (HBCs). T1DM增加了炎症,而GDM显示了SEH表达的改变和延迟状成熟,影响胎儿发育.

科学领域:

产科和妇科产科和妇科
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

胎盘炎症对母亲和胎儿都有风险.
糖尿病是一种常见的妊娠并发症.
霍夫尔细胞 (Hofbauer cells,HBCs) 是胎盘中的关键胎儿免疫细胞,在胎盘发育中起着关键作用.

研究的目的:

研究1型糖尿病 (T1DM) 和孕期糖尿病 (GDM) 患者的胎盘霍夫尔细胞 (HBC) 中的炎症标记物 (IL-1β,IL-10) 和特定酶 (CYP环氧酶,sEH) 的表达.
评估T1DM和GDM对胎盘小层结构和血管化的影响.

主要方法:

用免疫组织化学分析IL-1β,IL-10,CYP2C8,CYP2C9,CYP2J2和可溶性环氧化酶 (sEH) 在HBCs中的表达.
马森的三色染色被用来评估小层层结构.

主要成果:

1型糖尿病 (T1DM) 与增加IL-1β和降低HBCs中的CYP环氧酶表达有关.
孕期糖尿病 (GDM) 显示稳定的IL-1β和CYP环氧酶水平,但在HBCs中增加了SEH表达.
两种T1DM和GDM都表现出延迟的胎盘小成熟和低血管化,而GDM表现出更严重的影响.

结论:

IL-1β,CYP环氧酶和sEH的表达特征在对照和糖尿病胎盘之间,以及T1DM和GDM之间有显著差异.
该CYP环氧化酶-环氧化酸 (EETs) -sEH轴可能与IL-1β表达和胎盘低血管化有关.
稳定高IL-10表达表明,所有组的HBC中都保持了免疫耐受性.

关键词:

在CYP时代氧化酶酶中.孕期糖尿病孕期糖尿病霍夫巴乌尔的细胞是胎盘炎症胎盘炎症可溶性环氧化酸酶是可溶的环氧化酸酶.第1类糖尿病糖类糖尿病

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