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在口腔状细胞癌的术后放射治疗中,有或没有目标体积细分的瘤结果
Elena Riggenbach1, Manuel Waser2, Simon A Mueller2,3
1Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Frontiers in oncology
|April 9, 2024
概括
通过精制治疗体积,对口腔状细胞癌 (OCSCC) 的减强术后放射治疗 (PORT) 并没有影响局部区域控制. 这种方法可以减少毒性,而不会影响OCSCC患者的瘤学结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 头部和部癌症 头部和部癌症
背景情况:
- 术后放射治疗 (PORT) 在口腔状细胞癌 (OCSCC) 的体积影响毒性和生活质量.
- 目前的指导方针只允许PORT数量的最小减少.
- 正在研究PORT的精细细分,以减轻治疗的强度.
研究的目的:
- 在OCSCC患者中使用精细的分隔概念 (CC) 评估降强型PORT的安全性和有效性.
- 为了比较CC队列和历史队列 (HC) 之间的瘤结果.
主要方法:
- 从2014年至2019年,对103名OCSCC患者进行了回顾性队列研究,这些患者接受了精细细分 (CC) 治疗.
- 与在CC实施之前接受治疗的98名患者的历史队列 (HC) 进行比较.
- 基于精细的分隔,PORT被用于风险组.
主要成果:
- 随访时间中位数为4.5年 (CC) 和4.8年 (HC).
- 70%的CC患者因风险概况而减少了PORT的体积或省略了PORT.
- 在CC和HC队列之间的局部区域控制,无进展生存或其他结果中没有显著差异.
结论:
- 降低强度的PORT,仅限于高危人群或在低风险的OCSCC患者中省略,似乎是安全的,并且不会影响疾病控制.
- 这些发现支持在前性研究中进一步调查.
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