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在APC驱动的结直肠癌中改变脂质代谢:治疗干预的潜力

Courtney O Kelson¹, Yekaterina Y Zaytseva^1,2

¹Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.

Frontiers in oncology

|April 9, 2024

概括

改变的脂质代谢和APC基因突变导致结直肠癌. 本综述探讨了它们的相互联系,影响Wnt/β-catenin信号传递和促进癌症生长.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症新陈代谢癌症新陈代谢

背景情况:

改变的脂质代谢是固体癌症的标志,包括结直肠癌 (CRC).
异常的脂质代谢有助于CRC的启动,进展,转移和患者的不良结果.
腺多样性肠杆菌 (APC) 基因的失活突变是大多数CRC的早期事件,影响Wnt信号传递.

研究的目的:

综述和总结APC突变,Wnt/β-catenin信号传递和结直肠癌中的脂质代谢之间的交叉交流的有限理解.
阐明APC无活化和异常脂质代谢如何相互作用促进CRC.

主要方法:

文献综述和对现有APC,Wnt信号传递和CRC中的脂质代谢研究的综合.
在结直肠癌中分析遗传变化和代谢重编程之间的机制联系.

主要成果:

通过APC无活化和异常的脂质代谢,激活了Wnt/β-catenin信号传递.
这种激活导致转录组,表观遗传和微生物组的改变,驱动CRC启动和进展.
这些综合作用增强了癌症干,扩散,亲瘤信号和存活率.

结论:

了解APC无活化和改变的脂质代谢之间的机制联系至关重要.
这种知识可以确定新的治疗目标,以更有效地预防和治疗CRC.

关键词:

在APC基因APC基因.通过APC介导的信号传输.结肠直肠癌是什么意思脂质新陈代谢脂质新陈代谢脂质脂质脂质是一种

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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...