通过亚托皮状态改变喘儿童的COVID-19免疫力
Sherry Tong1, Jordan C Scott1, Enwono Eyoh1
1Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, La.
The journal of allergy and clinical immunology. Global
|April 9, 2024
概括
患有喘的儿童,特别是喘患者,在感染或接种疫苗后对SARS-CoV-2的免疫力较弱. 这可能会增加他们由于潜在的喘机制而再次感染的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染可能因严重喘而复杂.
- 喘患者的抗病毒免疫力往往受到损害,但其对儿童SARS-CoV-2免疫力的影响尚不清楚.
研究的目的:
- 评估患有喘的儿童的SARS-CoV-2免疫力.
- 为了比较SARS-CoV-2免疫力与对呼吸道同胞病毒和常见过敏原的反应.
主要方法:
- 在53名患有喘的儿童中评估了病史,肺功能和病毒/过敏原特异性免疫力.
- 利用抗体和T细胞测试来测量免疫反应.
主要成果:
- 大多数儿童在感染/接种疫苗后对SARS-CoV-2尖端蛋白产生多克隆抗体反应.
- 患有阿托皮性喘或高过敏原特异性IgE (特别是粉尘) 的儿童的SARS-CoV-2血清转化,抗体水平和中和减少.
- 特定的T细胞反应和细胞因子 (IL-17A,IL-21) 与SARS-CoV-2免疫力负相关,与总体和灰尘虫IgE不同. 喘控制不良与特定的细胞因子反应有关.
结论:
- 阿托皮性和非阿托皮性喘的潜在机制可能会影响到SARS-CoV-2感染或接种疫苗的记忆发展.
- 这种损伤可能会导致患有喘的儿童出现复发性SARS-CoV-2感染的风险增加.
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