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来自全血细胞计数的不同系统性炎症指数在区分急性和慢性结石胆囊炎以及预测其严重性的作用
1Department of Clinical Laboratory, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province, People's Republic of China.
Journal of inflammation research
|April 9, 2024
概括
像NLR和NLPR这样的系统性炎症指数可以帮助区分急性和慢性结石胆囊炎,并预测严重程度. 中性细胞与淋巴细胞的比率 (NLR) 最好区分ACC与CCC,而中性细胞与淋巴细胞×血小板的比率 (NLPR) 预测了ACC的严重程度.
科学领域:
- 胃肠病学和肝病学
- 炎症标志物研究研究
- 诊断准确性的研究研究.
背景情况:
- 全血清 (CBC) 衍生的炎症标志物越来越多地用于临床诊断.
- 区分急性结石胆囊炎 (ACC) 和慢性结石胆囊炎 (CCC) 对于适当的患者管理至关重要.
- 评估ACC的严重程度有助于治疗规划和预测患者的结果.
研究的目的:
- 评估CBC衍生的全身炎症指数 (NLR,PLR,SII,NLPR) 在区分ACC和CCC的诊断价值.
- 根据东京指南,评估这些指数在确定ACC严重性的有用性.
- 确定差异诊断和严重程度评估的最有效指数.
主要方法:
- 对105名CCC和88名ACC患者的回顾性分析.
- 评估中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),全身免疫炎症指数 (SII) 和中性粒细胞与淋巴细胞×血小板的比率 (NLPR).
- 进行了接收器操作特征 (ROC) 曲线分析和单变量/多变量回归分析.
主要成果:
- 与CCC患者相比,ACC患者的NLR,PLR,SII和NLPR水平显著更高.
- NLR>3.89显示了最高的预测能力 (AUC 0.801) 来区分ACC和CCC.
- 在ACC患者中,NLR和NLPR是区分轻度和中度至重度病例的重要独立预测因素.
结论:
- 从CBC衍生的炎症指数,特别是NLR和NLPR,是诊断ACC和评估其严重程度的宝贵工具.
- NLR是区分ACC和CCC的强有力的指标,而NLPR有效地预测了ACC的严重程度.
- 这些炎症标志物可以帮助临床医生对胆囊炎的风险分层和管理.
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