自闭症中感觉运动小脑的功能连接:与感觉过度反应相关联
Melis E Cakar1, Nana J Okada2,3,4, Kaitlin K Cummings3,4,5
1Neuroscience Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, United States.
Frontiers in psychiatry
|April 9, 2024
概括
自闭症谱系障碍 (ASD) 显示小脑的非典型功能,影响感官处理. 这项研究将ASD年轻人中大脑小连接的改变与感官过度反应 (SOR) 的严重程度联系起来.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 自闭症研究 自闭症研究
背景情况:
- 自闭症谱系障碍 (ASD) 经常与非典型的小脑发育和功能有关.
- 感官过度反应 (SOR) 是自闭症的常见和衰弱的症状,但它的神经支,特别是小脑贡献,尚未得到充分探索.
研究的目的:
- 与典型发育 (TD) 青年相比,研究ASD年轻人中感觉运动小脑的功能连接性.
- 检查传感运动大脑连接和ASD中SOR严重程度之间的关联.
主要方法:
- 在54名ASD和43名TD年轻人 (8-18岁) 中使用了休息状态功能连接MRI.
- 一个以种子为基础的分析专注于感觉运动大脑区域 (I-IV,V-VI,VIIA和B叶片).
- 连接模式在各组之间进行了比较,并与家长报告的SOR严重程度相关联.
主要成果:
- 感觉运动小脑表现出与感觉运动,视觉,边缘和更高阶感官区域的明显连接模式.
- 与TD年轻人相比,ASD年轻人表现出非典型的小脑内连接性和与海马体和丘脑的连接性增加.
- 较高的SOR严重程度与感觉/运动皮层区域的更强的连接以及认知/社会情绪区域的更弱的连接相关,特别是前额叶皮层.
结论:
- 在ASD中,感官运动小脑的异常功能连接可能是感官处理困难的基础.
- 这些发现突出了小脑在自闭症谱系障碍特征的感官挑战中的潜在作用.
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