骨髓炎与2型糖尿病患者的冠状动脉化有关
Fu-Peng Liu1,2, Mu-Jie Guo3, Qing Yang4
1The Affiliated Hospital of Medical College Qingdao University, Qingdao University, Qingdao 266071, Shandong Province, China.
World journal of diabetes
|April 9, 2024
概括
骨髓炎,或肌肉中的多余脂肪,是2型糖尿病 (T2DM) 患者冠状动脉化 (CAC) 的重要危险因素. 这一发现对于患有T2DM和较低传统动脉样硬化风险的年轻人来说尤为重要.
科学领域:
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
- 放射学 放射学是指放射学
背景情况:
- 骨髓炎是2型糖尿病 (T2DM) 中萨尔科佩尼亚的主要原因,超过了低肌肉质量.
- 这种情况有助于新陈代谢功能障碍,如胰岛素抵抗,炎症和氧化应激,加速T2DM和动脉样硬化.
- 这些代谢问题与T2DM和心血管疾病的进展密切相关.
研究的目的:
- 在T2DM患者中检查肌骨瘤和冠状动脉化 (CAC) 之间的关系.
- 为了确定骨髓炎作为潜在的动脉样硬化风险因素在这个人群中.
主要方法:
- 包括没有先前发生重大心血管事件的T2DM患者,他们接受了腹部和胸部CT扫描.
- 通过L3水平的腹部CT和CAC得分,通过使用Agatston方法对胸部CT进行评估的骨肌肉衰减 (骨髓变) 的平均值.
- 采用后勤回归和决策树分析,将严重的CAC (SCAC) 定义为分数>300.
主要成果:
- 在652名T2DM患者中,25.6%患有SCAC.
- 骨髓炎,年龄,糖尿病持续时间,吸烟和饮酒是SCAC的独立风险因素.
- 骨髓炎显著增加SCAC风险 (OR=2.381,P=0.003),特别是在年轻患者 (OR=2.672) 和动脉样硬化风险较低的患者中.
结论:
- 肌肉骨炎成为T2DM患者动脉样硬化的一个新风险因素.
- 这种联系在年轻人中更为明显,传统风险因素较少.
- 强调在T2DM管理中评估肌肉骨病的重要性,以对心血管风险分层进行分层.
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