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布普伦诺非因增强型的耐受性评估报告 (BETTER):一个案例系列
Claudia Epland1, Haley Pals2, John Hayden3
1Minneapolis Veterans Affairs Hospital, Minneapolis, MN, USA.
Substance use & addiction journal
|April 9, 2024
概括
延长释放型皮下布伦诺芬 (ER-BUP) 注射可能提供一种更耐受的选择,用于逐渐减少语言下布伦诺芬 (SL-BUP). 这种方法可以帮助管理戒断症状,减少阿片类药物使用障碍治疗中复发的风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
- 临床案例研究 临床案例研究
背景情况:
- 停止下舌布伦诺芬 (SL-BUP) 是一些阿片类药物使用障碍 (OUD) 治疗中的患者的目标.
- 由于阿片类药物戒断症状,减少SL-BUP可能具有挑战性,增加复发风险.
- 延长释放型皮下布伦诺芬 (ER-BUP) 是一种潜在的替代方案,用于在逐渐减少期间管理戒断.
研究的目的:
- 评估一次100毫克ER-BUP注射在SL-BUP逐渐缩小期间出现戒断的患者的使用情况.
- 描述患者的特征,不良影响和与ER-BUP用于逐渐缩小相关的结果.
主要方法:
- 对接受SL-BUP逐渐减速的8名患者进行了回顾性审查,这些患者接受了一次100毫克ER-BUP注射.
- 患者在注射前每天服用2-6毫克SL-BUP.
- 在注射后12个月内监测副作用,戒断症状和非法阿片类药物使用情况.
主要成果:
- 三名患者在注射后报告了轻微的不良反应,主要是那些服用较低的SL-BUP剂量 (2-3毫克) 的患者.
- 在12个月的时间里,3名患者出现了轻度,可容忍的戒断症状.
- 两名患者恢复了SL-BUP;没有患者恢复非法阿片类药物使用.
- 在注射后大约24周观察到布普伦诺芬的排泄.
结论:
- ER-BUP的逐渐缩小似乎比传统的SL-BUP的逐渐缩小更好地容忍,支持现有证据.
- 注射前的SL-BUP剂量为2-6毫克,可以最大限度地减少严重的不良反应和戒断.
- 在开始SL-BUP逐渐缩小之前,共享决策和确立缓解是至关重要的.
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