在社区实践中从儿童中分离出来的肺炎球菌与通过人口和实验室基础的侵入性疾病监测识别出来的隔离物不同
Ravinder Kaur1, Ryan Gierke2, Lesley McGee2
1Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York.
The Journal of infectious diseases
|April 9, 2024
概括
导致儿童耳部感染的肺炎球菌菌株与侵袭性疾病菌株不同. 非疫苗血清型35B越来越多地与这两种疾病有关,这凸显了更新疫苗策略的需要.
科学领域:
- * 微生物学与传染病
- * 疫苗学与公共卫生
背景情况:
- *了解肺炎球菌血清型分布对于评估肺炎球菌联合疫苗 (PCV) 的有效性至关重要.
- * 导致非侵入性和侵入性肺炎球菌病 (IPD) 的特征菌株可以为疫苗开发和公共卫生战略提供信息.
研究的目的:
- *为了比较肺炎球菌血清型分布和急性中耳炎 (AOM) 病例和儿童侵入性肺炎球菌疾病 (IPD) 病例之间的抗生素不敏感性.
- *识别新出现的血清型及其与抗生素耐药性的关联.
主要方法:
- *分析来自纽约罗切斯特 (2011-2019) AOM儿童的鼻和中耳液 (MEF) 肺炎球菌分离物.
- *与来自美国的活性细菌核监测系统 (ABCs) 的IPD分离物进行比较.
- *评估血清型分布和抗生素耐药性模式.
主要成果:
- *在AOM和IPD病例之间观察到不同的血清型分布.
- *非疫苗血清型35B和21在罗切斯特AOM病例中更为普遍.
- *35B血清型在2015-2019年间成为抗生素不敏感的AOM和IPD的常见原因.
结论:
- *罗切斯特的儿科AOM病例中的肺炎球菌分离体与IPD病例相比,表现出不同的血清型和抗生素敏感性概况.
- *非疫苗血清型35B在AOM和IPD中出现的情况强调了其作为公共卫生问题的重要性.
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