甲状腺结节管理中的偏好表型:一种患者细分方法
Matthew R Naunheim1,2, Isaac Wasserman1,2, Manuela R von Sneidern1,2
1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
概括
患者对甲状腺结节管理的偏好至关重要. 癌症风险和药物需求显著影响决策,有不同的患者群体被确定为个性化护理.
科学领域:
- 内分泌学 在内分泌学.
- 医疗保健服务研究 医疗服务研究
- 决策科学 决策科学 决策科学
背景情况:
- 对于治疗甲状腺结节的患者偏好尚不清楚.
- 了解这些偏好是甲状腺疾病中共同决策的关键.
研究的目的:
- 使用离散选择实验 (DCE) 探索甲状腺结节管理中的患者风险权衡.
- 为量身定制的治疗方法,将患者分为不同的偏好表型.
主要方法:
- 设计了一个离散选择实验 (DCE),其中包括癌症风险,语音问题,痕,药物和随访等属性.
- 对1026名参与者 (480名甲状腺疾病患者) 进行了DCE,并提出了人口统计和风险耐受性问题.
- 用多项逻辑模型和隐性类分析 (LCA) 来进行数据分析和偏好表型化.
主要成果:
- 癌症风险 (47.8%) 和药物管理 (20.0%) 是影响患者决策的最重要因素.
- 潜在类分析发现了三种不同的偏好表型:以癌症风险为重点 (64.2%),药物不良反应 (18.2%) 和均衡 (17.7%).
- 风险厌恶与年龄,女性性别和教育水平较低相关.
结论:
- 患者对甲状腺结节的决定受到癌症风险和手术后药物需求的严重影响.
- 该研究确定了不同的患者偏好表型,强调了治疗甲状腺疾病的个性化评估的必要性.
相关概念视频
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