暴露于per-和多基物质和骨健康:系统性审查和元分析
Mohammad Ali Khosrojerdi1, Hadi Lotfi2, Zeinab Babaei3
1Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.
International journal of environmental health research
|April 9, 2024
概括
和多醇基物质 (PFAS) 的暴露与较低的骨矿物质密度有关. 某些PFAS,如 perfluorohexane sulfonate (PFHxS),与骨质疏松症风险增加有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 和多基基物质 (PFAS) 是广泛存在的环境污染物.
- PFAS暴露与人类骨健康,特别是骨质疏松症之间的关系需要澄清.
- 现有研究对PFAS和骨健康参数提出了相互矛盾的发现.
研究的目的:
- 系统地审查和对现有文献进行元分析.
- 评估PFAS暴露与人类骨健康参数之间的关系.
- 为了澄清PFAS和骨质疏松症之间的有争议的联系.
主要方法:
- 观察性研究的系统审查和元分析.
- 在2023年12月2日之前进行文献搜索,获取了2096篇文章.
- 在选了21篇相关文章后,将10项研究纳入最终的元分析.
主要成果:
- 血清中 perfluorooctanoic acid (PFOA) 和 perfluorooctane sulfonic acid (PFOS) 的水平增加与全身减去头骨矿物质密度 (TBLH-BMD) 有负相关.
- PFOA的翻倍与β值为-0.11 (95% CI: -0.18, -0.05) 相关.
- PFOS的翻倍与β值为-0.06 (95% CI: -0.11, -0.01) 相关.
- perfluorohexane sulfonate (PFHxS) 的暴露与骨质疏松症有显著的相关性 (OR = 1.37,95% CI: 1.12,1.68).
结论:
- perfluorohexane sulfonate (PFHxS) 暴露与骨质疏松症的可能性增加有显著的相关性 (OR = 1.37,95% CI: 1.12,1.68).
- 这些发现表明,特定的PFAS化合物可能会对骨健康产生负面影响.
- 需要进一步的研究来了解将PFAS和骨质疏松症联系在一起的机制.
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