在孩子口的链球菌血清学
Tulin Fidan1, Serkan Ceyhan2, Vural Fidan2
1Child and Adolescent Psychiatry Department, Eskisehir Osmangazi University Hospital, Eskisehir, Turkey.
Ear, nose, & throat journal
|April 9, 2024
概括
吃的孩子表现出更高水平的抗思球菌抗体,这表明潜在的自身免疫链接到A组β-溶血性思球菌. 对于口吃的儿童,建议对自身免疫反应进行进一步检查.
科学领域:
- 儿科神经学 儿科神经学
- 免疫学 免疫学 免疫学
- 语音语言病理学 语言病理学
背景情况:
- 吃是一种语言障碍,其特点是流利性受到干扰.
- 与链球菌感染 (PANDAS) 相关的儿科自身免疫神经精神疾病与A组β-溶血性链球菌 (GABHS) 有关.
- 以前的报道表明PANDAS和口吃之间存在联系,并指出与图雷特综合征有共同的特征.
研究的目的:
- 调查链球菌血清学与儿童口吃之间的关联.
- 为了确定在吃的儿童 (CWS) 中是否存在升高的抗斯特雷普托可克抗体.
主要方法:
- 分析了26名口吃的孩子和25名不口吃的孩子的血清样本,根据年龄和性别进行了匹配.
- 测量的主要抗菌抗体包括抗菌素O (ASO),抗脱氧核糖核酶B (抗DNase B) 和抗菌酶.
- 统计分析比较了口吃和不口吃组之间的抗体水平.
主要成果:
- 与没有口吃的儿童相比,口吃的儿童表现出明显更高的ASO,抗DNase B和抗思基酶水平 (所有儿童的P < .0001).
- 这些发现表明,在吃的儿童中,对GABHS的免疫反应加剧.
结论:
- 在CWS中血清抗菌抗体升高表明与GABHS相关的潜在自身免疫病因.
- 对自免疫反应进行临床评估,特别是对GABHS进行临床评估,对于吃的孩子来说是有必要的.
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