精神分裂症的肠道透性和低度慢性炎症:生物标志物的多中心研究. 理由,目标,协议和初步结果
Gerard Anmella1, Silvia Amoretti2, Gemma Safont3
1Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Institute of Neuroscience, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain; Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain; Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona, Institute of Neuroscience, University of Barcelona, IDIBAPS, Spain.
Spanish journal of psychiatry and mental health
|April 9, 2024
概括
这项研究调查了精神分裂症中的微生物群-肠-大脑轴,探索肠道透性,炎症和疾病特征之间的联系. 这些发现旨在改善对精神分裂症谱系障碍的理解和个性化治疗.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 改变肠道透性和慢性炎症通过微生物群-肠道-大脑轴与精神分裂症病理生理学有关.
- 关于精神分裂症中微生物群-肠-大脑轴的现有研究是不一致的.
- 这个项目研究了肠道健康和精神分裂症之间的关系.
研究的目的:
- 评估精神分裂症谱系疾病中肠道透性和慢性炎症之间的相互关系.
- 探索外围生物标志物的作用,饮食,运动,代谢综合征,疾病严重程度,功能和认知.
- 为了解精神分裂症病理生理学和个性化治疗做出贡献.
主要方法:
- 这是一项对646名患有DSM-5精神分裂症谱系障碍的成年患者的观察性,横截面,多站点研究.
- 评估包括人类学,肠道透性,饮食,体育炼,临床和功能状态,神经心理测试,认知储备和外周血液生物标志物.
- 从西班牙的四个中心收集的数据.
主要成果:
- 招募了646名患者 (39.7%为女性),平均年龄为43.2岁,疾病持续时间为15.1年.
- 55.8%的人消费烟草.
- 记录了PANSS,CGI和GAF分数的描述性数据.
结论:
- 预计将提高对精神分裂症谱系障碍病理生理学的理解.
- 这些发现可能有助于通过结合肠道透性和炎症变量来个性化治疗.
- 在管理精神分裂症方面改善现实世界的临床实践的潜力.
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