第一次精神分裂症的负面症状和性别差异:它们在功能结果中的作用是什么? 一个纵向研究研究
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Silvia Amoretti1, Gisela Mezquida2, Norma Verdolini3
1Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Psychiatric Genetics Unit, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain; Barcelona Clinic Schizophrenia Unit, Hospital Clinic, Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Institut d'Investigacions Biomèdiques, August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Bipolar and Depressive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; Institute of Neurosciences (UBNeuro), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Psychiatry, University of Perugia, Perugia, Italy.
患有第一发精神分裂症的女性经历的负面症状较少,特别是表达力下降. 针对激励和快乐的早期干预可以改善精神分裂症患者的功能结果.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 精神分裂症的负面症状 (NS),包括 asociality, avolition, anhedonia, alogia,和形影响,与预后不佳有关.
- NS可能包括两个因素:表达力下降 (EXP) 和动机/快乐 (MAP).
- 了解NS的性别差异及其预测因素对于有针对性的干预至关重要.
研究的目的:
- 调查第一发精神分裂症 (FES) 患者负面症状的潜在性别差异.
- 分析NS因子 (EXP和MAP) 和功能结果的与性别相关的预测因子.
- 探索NS,病前调整,抑郁症状和功能之间的关系.
主要方法:
- 一组223名FES患者 (71名女性,152名男性) 在基线,6个月和1年被评估.
- 重复测量ANOVA检查了时间和性别对NS的影响.
- 多重线性回归确定了NS因子 (MAP-EXP) 的预测因子和功能.
主要成果:
- 与男性相比,女性表现出较少的NS (p=0.031) 和EXP症状 (p=0.024).
- 更糟糕的病前调整和更高的抑郁症状预测了两性中更高的EXP缺陷.
- 积极和抑郁症状预测了MAP的变化,而较低的MAP赤字和更好的预先疾病调整预测了女性更好的功能.
结论:
- 在FES患者中观察到负面症状的细微性别差异.
- 针对动机和快乐症状 (MAP) 的干预措施可能会提高功能结果.
- 建议对NS采取早期干预策略,以改善精神分裂症的长期预后.
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