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比利时的传染性内心炎:来自ESC EORP欧洲内心炎登记处成年人的前性数据
Bram Roosens1, Bernard Cosyns1, Patrizio Lancellotti2
1Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium.
Journal of clinical medicine
|April 9, 2024
概括
比利时的传染性内心炎 (IE) 影响着老年男性,黄金葡萄球菌和未进行的手术是主要的死亡率预测因素. 这项研究提供了对IE患者个人资料和结果的见解.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 临床研究 临床研究
背景情况:
- 传染性内心炎 (IE) 是一个重大的全球健康挑战,患病率和死亡率很高.
- 关于比利时的IE存在有限的回顾性数据,需要当代的前性研究.
- 该研究解决了关于比利时IE患者特征和结果的最新信息的需求.
研究的目的:
- 为了前性地评估比利时感染性内心炎患者的临床特征和结果.
- 分析ESC EORP欧洲内心炎 (EURO-ENDO) 注册表中的数据.
- 为了确定比利时IE患者死亡率的预测因素.
主要方法:
- 预计将在比利时六家三级医院招收132名感染性内心炎患者.
- 根据欧洲心脏病学会 (ESC) 2015年标准进行诊断.
- 收集有关患者人口统计,受影响的门,致病微生物,并发症,治疗和死亡率的数据.
主要成果:
- 平均患者是男性,年龄为62.8岁. 原生门最常受到影响 (56.8%),假肢/修复门 (34.1%) 和与设备相关的 (5.3%) IE 的比例增加.
- 金黄色葡萄球菌 (37.2%) 是最常见的病原体,其次是肠球菌和病毒球菌链球菌 (15.5%). 急性功能衰竭 (36.2%) 和栓塞性事件 (23.6%) 是最常见的并发症.
- 住院死亡率为15.7%. 黄金葡萄球菌感染 (HR=2.99) 和心脏手术 (HR=19.54) 是显著的预测死亡率.
结论:
- 欧欧-ENDO注册表的前性分析提供了比利时传染性内心炎的关键当代数据.
- 黄金葡萄球菌和未进行心脏手术是影响死亡率的关键因素.
- 这些发现强调了及时的手术干预和向的抗菌药物治疗在管理IE方面的重要性.
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