在MRI阴性药物耐药性患者中识别异常的闭环通路
Jinxin Bu1, Nanxiao Ren1, Yonglu Wang2
1Department of Functional Neurosurgery, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Brain imaging and behavior
|April 9, 2024
概括
研究人员在患者中确定了异常的大脑网络通路,可能有助于诊断和个性化治疗. 这些全脑网络异常与的认知和情绪障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 医疗成像医学成像
背景情况:
- 是一种大脑网络障碍,经常伴随着认知和情绪缺陷.
- 目前关于闭环途径的研究仅限于神经元水平或已知的途径,缺乏全脑网络分析.
- 对中全脑网络异常的研究很少.
研究的目的:
- 在磁共振成像阴性药物耐药性 (MRIneg-PRE) 患者中研究稳定的闭环通路中的全脑网络异常.
- 在MRIneg-PRE中确定异常闭环路径和认知/情绪障碍之间的关联.
- 探索这些途径作为诊断生物标记物的潜力.
主要方法:
- 从26名MRIneg-PRE患者和26名健康对照 (HC) 的休息状态功能性MRI数据构建了因果和时间延迟大脑网络.
- 利用约翰逊算法识别稳定的闭环路径.
- 进行了皮尔森相关性分析,以检查异常路径和损伤之间的关联.
主要成果:
- 与HC相比,MRIneg-PRE患者的额叶,额叶和叶分布的异常稳定闭环通路被确定.
- 观察到大脑半球内和大脑半球之间功能连接的改变.
- 在叶中发现了四条异常的闭环通路,与情绪和认知障碍相关.
结论:
- 整个大脑网络中的异常稳定闭环通路存在于MRIneg-PRE中.
- 这些通路,特别是在叶,与认知和情绪缺陷相关.
- 异常的闭环路径可以作为诊断MRIneg-PRE和指导个性化治疗的生物标志物.
更多相关视频
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
2.6K
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
11.2K
相关概念视频
01:24Arteries of the Lower Limbs
188
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
188
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
388
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
388