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一种新型三基希夫基 (II) 复合物的合成,理论分析和生物特性

Samira Jahangiry¹, Maryam Lashanizadegan², Pouneh Sadat Pourhosseini³

¹Department of Inorganic Chemistry, Faculty of Chemistry, Alzahra University, Tehran, Iran.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

|April 9, 2024

概括

一种新型的 (II) 希夫基复合物,在水性缓冲中稳定,通过与DNA相互作用,显示出显著的抗癌和抗菌活性. 与黄素相比,它的抗氧化能力降低了.

科学领域:

生物有机化学生物有机化学
协调化学协调化学
药用化学医学化学

背景情况:

希夫基复合物在生物无机化学中至关重要.
基于黄素的配体提供了潜在的治疗应用.
在生理条件中的稳定性对于药物开发至关重要.

研究的目的:

为了合成和表征一种新的,水稳定的黄素/氨酸希夫基拉 (II) 复合物.
研究该复合体与DNA的相互作用及其生物活性 (抗癌,抗菌,抗氧化剂).
探索治疗应用的潜在作用机制.

主要方法:

希夫基联体和 (II) 复合物的合成.
使用DFT,NBO,FMO和MESP分析进行结构性阐明.
使用光火的DNA结合研究 (等离子体和CT-DNA).
生物活性测定:细胞毒性的MTT,抗菌性的MIC,抗氧化剂的DPPH.
使用单向ANOVA和Tukey测试进行统计分析.

主要成果:

合成的复合物在pH 8的水性缓冲物中稳定.
复杂化导致DNA的光灭,表明相互作用.
对MCF-7细胞具有显著的抗癌活性 (IC50 = 72.47μM) 和对大肠杆菌和金黄色杆菌的抗菌活性 (MIC分别为300和200μg/mL).
对大肠杆菌和黄金杆菌观察到的高生物膜抑制 (96.3%和95.2%).
该复合物的抗氧化活性 (DPPH测定) 低于父黄素.

结论:

(II) 希夫基复合物表现出有希望的抗癌和抗菌特性,可能通过DNA相互作用进行介导.
该复合物有效地抑制细菌生长和生物膜的形成.
虽然该复合物在水性介质中稳定,但与黄素相比,其抗氧化能力有所降低,这表明其修饰性质的权衡.

关键词:

库尔库明是一种黄素.在 DFT 方面,它是最重要的.结合 DNA 的 DNA 结合.光灭的光灭方式帕拉是什么意思?帕拉是什么意思?这里是船只基地.

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