怀孕期间使用乙氨基和儿童患自闭症,多动症和智力障碍的风险
Viktor H Ahlqvist1, Hugo Sjöqvist1, Christina Dalman1
1Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
JAMA
|April 9, 2024
概括
在怀孕期间使用乙氨基并没有增加儿童患自闭症,多动症或智力障碍的风险. 兄弟对照分析表明以前的关联可能是由于家族因素, 而不是药物本身.
科学领域:
- 神经发育障碍
- 孕妇的健康
- 儿童健康
背景情况:
- 在怀孕期间通常使用乙氨基 (偏醇) 缓解疼痛和发烧.
- 之前的研究表明,产前乙氨基暴露与儿童神经发育障碍的风险增加之间存在潜在联系.
- 澄清这种关联对于指导临床实践和确保母亲和儿童的福祉至关重要.
研究的目的:
- 调查怀孕期间使用乙氨基与自闭症谱系障碍 (ASD),注意力缺陷/多动症障碍 (ADHD) 和后代智力障碍的风险之间的联系.
- 为了区分药物效应与潜在的家族混因素.
主要方法:
- 瑞典的一项全国性队列研究包括1995年至2019年间出生的超过240万名儿童.
- 从产前和处方记录中确定了对乙胺的暴露.
- 用兄弟控制分析来解释家庭内共同的遗传和环境因素.
主要成果:
- 原始分析显示,随着产前对乙氨基的暴露,自闭症,多动症和智力障碍的风险略有增加.
- 然而,兄弟对照分析发现,在怀孕期间使用乙氨基与这些神经发育障碍的风险之间没有统计学意义上的关联.
- 在兄弟分析中没有观察到剂量反应关系.
结论:
- 在产前使用乙氨基并没有增加儿童患自闭症,多动症或智力障碍的风险.
- 这些发现表明,家庭混,而不是乙氨基本身,可能解释了先前观察到的关联.
- 这项研究提供了强有力的证据,支持在医学上适用的情况下在怀孕期间继续使用乙氨基来控制疼痛和发烧.
更多相关视频
19:57The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
8.4K
03:19Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
409
相关概念视频
Attention-Deficit/Hyperactivity Disorder
57
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
57
Autism Spectrum Disorder
88
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
88
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Environmental Influences on Intelligence
285
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
285
Intellectual Disability
49
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
49
