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成年人因温克里斯诱导的外周神经病变的特征:症状的发展和长期持久的结果
Tiffany Li1,2, Terry Trinh3, Annmarie Bosco3,4
1Brain and Mind Centre, The University of Sydney, Sydney, Australia.
概括
温克里斯诱导的周围神经病变 (VIPN) 影响大多数成年患者,导致感觉运动问题和残疾. 虽然有所恢复,但长期症状可能会持续,影响生活质量.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 文克里斯是治疗血液性恶性瘤的关键化疗.
- 温克里斯诱导的周围神经病变 (VIPN) 是一种常见的,使人衰弱的,无法治疗的副作用.
- 缺乏对成人VIPN特征的全面了解.
研究的目的:
- 在成年患者中进行温克里斯诱导的外周神经病变的详细表型.
- 描述VIPN的感觉运动症状,功能影响和恢复模式.
主要方法:
- 对57名成年患者的横截面和前性评估. 在温克里斯治疗后.
- 使用患者报告的结果 (EORTC-QLQ-CIPN20,R-ODS) 和神经评估 (总神经病变得分,神经传导研究).
- 包括感觉值和精细运动任务;使用t测试和曼·惠特尼U测试进行的统计比较.
主要成果:
- VIPN在治疗中期的77.8%患者中发生,并在治疗结束时的75%患者中持续存在.
- 在治疗后3个月,50%的患者仍然报告了VIPN,神经分级和功能显著改善.
- VIPN表现为上肢和下肢的感觉运动缺陷,与神经幅度降低,精细运动能力受损和残疾增加有关.
结论:
- 成年人的VIPN是一种感觉运动神经病变,影响上肢和下肢,显著损害功能和增加残疾.
- 虽然有些患者经历神经病变恢复,但VIPN症状可能会持续,影响长期的生活质量.
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