Cynara cardunculus L. var. 在这里可以看到. 兰德拉斯"Carciofo Ortano"作为生物活性化合物的来源
Valentina Laghezza Masci1, Enrica Alicandri1, Chiara Antonelli1
1Department for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.
Plants (Basel, Switzerland)
|April 9, 2024
概括
来自"Carciofo Ortano"桃的农业副产品含有丰富的有益生物分子. 这些提取物显示有选择性的抗癌作用和强大的抗真菌活性,提供多功能应用.
科学领域:
- 农业科学 农业科学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 农业生物多样性和社会经济发展对于生产和创新至关重要.
- 菜种植,特别是"Carciofo Ortano"陆地品种,产生大量的副产品,如叶子,茎和根.
- 这些副产品代表了有价值的生物分子和益生菌食纤维的潜在来源.
研究的目的:
- 为了利用"Carciofo Ortano"大桃陆地品种的叶子废物.
- 为了识别和描述在桃叶提取物中存在的生物分子.
- 评估这些提取物的生物活性,包括抗增殖性,细胞毒性和抗菌作用.
主要方法:
- 多学科方法包括化学分析 (HPLC-DAD,SPME-GC/MS) 和生物分析.
- 使用二极管阵列检测 (HPLC-DAD) 的高性能液体染色学,用于识别化合物.
- 固态微提取气体染色学/质谱学 (SPME-GC/MS) 用于挥发性化合物分析.
- 对人类癌症和正常细胞系进行体外研究,以评估抗增殖和细胞毒性作用.
- 针对细菌和真菌菌株的抗微生物测定.
主要成果:
- 在HPLC-DAD中确定了桃叶提取物中的单-O-和di-O-caffeoylquinic酸和cynaropicrin.
- 在新鲜的叶子样本中,SPME-GC/MS检测到亚利法醇.
- 花叶提取物在测试的癌症细胞系上表现出选择性,剂量和时间依赖的抗增殖和细胞毒性作用.
- 提取物对植物病原菌*Alternaria alternata*具有显著的抗真菌活性.
- 观察到对环境细菌菌株的活性有限.
结论:
- "Carciofo Ortano"桃的叶子废物是生物活性化合物的宝贵来源.
- 这些副产品具有选择性的抗癌特性和强大的抗真菌活性.
- 这些发现支持对农业副产品的价值化,用于人类健康,动物料和环境管理的各种应用.
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