在重症监护病房中与COVID-19患者和没有COVID-19患者的Candida殖民的比较:土耳其的第一个前性队列研究
Ilvana Çaklovica Küçükkaya1, Günseli Orhun2, Arif Atahan Çağatay3
1Istanbul University Istanbul Faculty of Medicine, Department of Medical Microbiology, 34093, Istanbul, Turkey.
Medical mycology
|April 9, 2024
概括
在COVID-19重症监护室 (ICU) 的患者表现出较高的Candida殖民率,特别是在非白物种中,但感染率与非COVID-19患者相似. 这凸显了监测和潜在的治疗耐药性的必要性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 密集护理医学 密集护理医学
背景情况:
- 坎迪达菌种是重症监护室 (ICU) 中真菌感染的主要原因.
- 在COVID-19ICU患者中,关于Candida殖民进展的信息有限.
- 了解殖民动态对于管理潜在的感染至关重要.
研究的目的:
- 为了前性地比较Candida殖民和COVID-19中的感染发展与非COVID-19的ICU患者.
- 为了识别孤立的Candida物种,风险因素和殖民率.
- 评估不同患者群体中殖民模式的临床影响.
主要方法:
- 一项前性研究比较了62名COVID-19和60名非COVID-19的ICU患者.
- 从入院到出院的间隔内收集1464个样本 (口腔,皮肤,直肠,尿液).
- 使用CHROMagar Candida介质和MALDI-TOF MS.识别Candida分离物
主要成果:
- 在COVID-19患者中,口腔,直肠和尿液中的Candida殖民率显著更高 (p <0.05).
- 在COVID-19患者中,非白虫Candida物种更频繁,特别是口服和直肠 (p < 0.001).
- 机械通风和皮质类固醇使用被确定为COVID-19患者的危险因素 (p < 0.05).
- 坎迪达感染的发病率很低,在两组之间没有显著差异 (9.67%对6.67%).
结论:
- 虽然Candida殖民性在COVID-19ICU患者中较高,但感染率与非COVID-19患者相比较.
- 在COVID-19患者中增加了非白虫Candida的检测,这表明预防性/经验性治疗可能面临挑战.
- 混合殖民率高,强调了染色基媒对于常规Candida监测的有用性.
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