在亚微米呼吸道气溶中,相对湿度依赖的相位过渡
Angel M Gibbons1, Paul E Ohno1
1Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, United States.
The journal of physical chemistry. A
|April 9, 2024
概括
微微微的呼吸气溶经历液-液相分离,影响病毒的生存能力和传播. 了解这些对气溶性质的环境影响是控制呼吸道疾病传播的关键.
科学领域:
- 环境科学 环境科学
- 气溶科学 气溶科学
- 病毒学 病毒学
背景情况:
- 流感和SARS-CoV-2等呼吸道病毒对公共健康构成重大风险.
- 传播通过呼吸道滴和气溶发生,受环境因素的影响,如相对湿度 (RH) 和温度.
- 以前的研究将超微米粒子中的依赖RH的相变与病毒活力联系起来.
研究的目的:
- 为了研究亚微米模型呼吸气溶中的相位过渡.
- 了解环境因素对亚微米气溶特性的影响.
- 展示一种基于光的方法,用于研究微米级呼吸道粒子的行为.
主要方法:
- 准备模型呼吸气溶液 (/盐混合物,生长介质,模拟肺液).
- 添加了一个探针分子,尼罗河红色,以检测相位过渡.
- 在RH调节后测量了极度依赖的光辐射.
主要成果:
- 在亚微米/NaCl和生长介质颗粒中观察到液态-液态相分离 (LLPS).
- 使用光测量,在亚微米气溶中的相位过渡得到了确认.
- 这项研究证明了 in situ光对于分析亚微米粒子属性的实用性.
结论:
- LLPS发生在微微米呼吸气溶中,类似于较大的颗粒.
- 亚微米气溶LLPS可以影响病毒活力和气溶传播.
- 基于光的测量对于研究微米级呼吸道颗粒的物理化学性质是有效的.
相关概念视频
Phase Transitions: Sublimation and Deposition
17.1K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
17.1K
Phase Transitions: Vaporization and Condensation
17.6K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase...
17.6K
Phase Transitions
19.1K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
19.1K
Phase Diagrams
40.6K
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
40.6K
Acute Respiratory Failure-II
218
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
218
States of Matter and Phase Changes
947
The internal energy of a substance—the total kinetic energy of all its molecules and the potential energy of their associated forces—depends on the strength of the intermolecular forces in the condensed phases and the pressure exerted on the substance. The internal energy of a substance is the highest in the gaseous state, the lowest in the solid state, and intermediate in the liquid state. Phase transitions are caused by changes in physical conditions, such as temperature and...
947


