基于Compritol®的固体脂质纳米颗粒的desvenlafaxine,通过超声波辅助热封装来制备,以修改其释放
Huma Rao1, Iqra Rao2, Saeed Ahmad1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab, 63100, Pakistan.
Nanomedicine (London, England)
|April 9, 2024
概括
固体脂质纳米颗粒 (SLN) 提供了一个解决方案,以快速释放desvenlafaxine (DES) 从常规形式. 这种配方成功地实现了持续的药物释放,最大限度地减少了与初始突发释放相关的副作用.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 传统的desvenlafaxine (DES) 配方表现出最初的爆发释放,可能会加剧副作用.
- 康普里托尔® 888 ATO是一种脂质辅助剂,可以减轻持续释放剂型的突发释放.
研究的目的:
- 为了研究装有desvenlafaxine的固体脂质纳米颗粒 (DES-SLNs) 对修改药物释放的潜力.
- 评估使用康普里托尔® 888 ATO 在为DES创建持续释放配方时的使用情况.
主要方法:
- 通过超声波辅助的热封装合成了DES-SLNs.
- 分析了体外药物释放概况,以评估释放动力学和爆发效应.
主要成果:
- 合成的DES-SLNs表现出65.90%的高捕获效率.
- 试验室研究显示持续释放的行为,超过16小时81%的累积药物释放.
- 该配方成功地消除了desvenlafaxine的最初突发释放.
结论:
- DES-SLN 是一种有前途的载体系统,可以持续地输送水溶性抗抑郁药物,如德斯文拉法辛.
- 这种方法提供了一种策略,通过控制其释放率来改善德斯文拉法辛的治疗特征.
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