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在具有短期可塑性的正规皮质电路中进行自上而下的调制

Felix Waitzmann^1,2, Yue Kris Wu^1,2, Julijana Gjorgjieva^1,2

¹School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.

Proceedings of the National Academy of Sciences of the United States of America

|April 9, 2024

概括

皮层网络中的短期可塑性与多种内部神经元使反应逆转. 帕瓦胺内部神经元抑郁严重影响体静止素神经元反应逆转,揭示了非线性网络动态.

科学领域:

神经科学是一个神经科学.
计算神经科学是一种神经科学.
系统神经科学系统神经科学

背景情况:

皮层计算依赖于与激发性神经元相互作用的各种GABAergic内部神经元 (帕瓦尔胺,索马托斯塔丁,血管活性肠).
这些网络表现出非线性现象,例如反应逆转,神经元反应根据输入上下文和神经调节而改变.

研究的目的:

研究多个内核神经网络中的短期可塑性机制如何促进像反应逆转这样的非线性现象.
阐明不同内部神经元亚型及其可塑性在网络动态和稳定中的特定作用.

主要方法:

采用分析和计算建模方法.
将实验识别的短期可塑性机制纳入具有多个内部神经元亚型 (PV,SST,VIP) 和激发性神经元的网络模型.

主要成果:

模型网络成功实现了反应逆转,其中体静止素 (SST) 神经元对血管活性肠 (VIP) 调节的反应取决于感官输入.
从parvalbumin (PV) 到激发性 (E) 神经元的短期抑郁显著影响了SST反应的逆转,尽管它没有直接影响SST或VIP活动.
反应逆转与SST神经元介导的网络稳定性变化有关,突出了塑性在网络状态转换中的作用.

结论:

短期可塑性机制对于产生多个内部神经元类型的皮质网络中的非线性现象至关重要.
在SST响应逆转和网络稳定方面,光伏到电的短期抑郁起着关键的,尽管间接的作用.
该研究提供了实验可测试的预测,关于内部神经元亚型的相互作用和皮质功能中的短期可塑性.

关键词:

抑制稳定抑制稳定内部神经元内部神经元内部神经元这是一个悖论性的效应.短期的可塑性是短期的可塑性.

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