年轻胃癌患者的转移模式和预后:与倾向性得分相匹配的SEER数据库分析
Hong Zhang1,2, Xia Cheng3, Wenqin Guo4
1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, China.
PloS one
|April 9, 2024
概括
患有转移性胃癌 (GC) 的年轻患者表现出明显的转移模式和比老年患者更好的整体生存结果. 然而,年龄没有影响胃癌特异性存活率,转移模式因年龄组而异.
科学领域:
- 在瘤学瘤学.
- 癌症转移 癌症转移
- 流行病学 流行病学
背景情况:
- 年轻患者的转移性胃癌 (GC) 存在独特的挑战,与老年人相比,关于转移模式和生存结果的有争议的发现.
- 了解这些差异对于定制治疗策略和改善患者预后至关重要.
研究的目的:
- 调查年轻人与老年患者转移性GC转移的转移模式.
- 确定影响年轻转移性GC患者生存的预后因素.
- 为了比较年轻和老年转移性GC患者队列之间的生存结果.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库 (2010-2015) 识别了5580名转移性GC患者.
- 患者分为年轻 (≤40岁) 和年长 (>40岁) 的两组.
- 采用千二测试,卡普兰-梅尔,考克斯回归和倾向分数匹配 (PSM) 进行比较分析.
主要成果:
- 较年轻的患者 (n=237) 比较年长的患者 (n=5343) 在PSM前后具有较高的仅骨转移率和较低的仅肝转移率.
- 年轻是整体存活率 (OS) 的独立保护因素,但不是胃癌特定存活率 (GCSS).
- 在年轻患者中,仅肝转移提供了最好的预后,而仅肺转移显示出明显更差的结果,与骨转移相比较.
结论:
- 年轻的转移性GC患者表现出更具侵略性的瘤,但与老年同行相比,矛盾的是更好的预后.
- 在GC中转移模式因年龄而异,显著影响患者的预后.
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