在口腔状细胞癌中Toll类受体的表达
Peter Rusanen1, Emilia Marttila2, Sajeen Bahadur Amatya3
1Department of Bacteriology and Immunology, Haartman institute, University of Helsinki, Helsinki, Finland.
PloS one
|April 9, 2024
概括
这项研究发现,在口腔状细胞癌 (OSCC) 组织中,Toll-like受体 (TLR) 和NF-κB的表达较低. 坎迪达菌种植与OSCC中TLR4表达的增加有关.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 口腔病理学 口腔病理学
背景情况:
- 口腔状细胞癌 (OSCC) 是一个主要的全球健康问题,占口腔癌的90%.
- 收费类受体 (TLRs) 越来越多地参与各种致癌过程.
- 了解OSCC中的TLR表达对于识别潜在的治疗点至关重要.
研究的目的:
- 与健康的口腔粘膜相比,研究OSCC中Toll类受体 (TLR1-10) 和NF-κB的表达水平和组织局部化.
- 评估Candida殖民对OSCC中TLR表达的影响.
主要方法:
- 分析了30名OSCC患者和26名健康对照的全厚活检和微生物样本.
- 免疫组织化学被用来确定TLR1-10和NF-κB的表达.
- 微生物分析在口腔粘膜样本中发现了Candida殖民.
主要成果:
- 与健康对照人群相比,OSCC表皮和底层膜区域显示了几个TLRs (TLR1,2,3,4,5,7,8) 的显着较低的表达.
- 在OSCC组织中,NF-κB表达显著减少.
- 在OSCC的基底层中观察到NF-κB,TLR9和TLR10表达之间的正相关性.
- 坎迪达菌种植与OSCC的底层膜区的TLR4表达增加有关.
结论:
- 该研究表明,在OSCC中TLR和NF-κB的下调.
- 在OSCC中存在Candida殖民时,TLR4表达被上调.
- 这些发现表明TLRs在OSCC的发展和进展中起着复杂的作用.
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