铁和雌激素在更年期内对心脏代谢结果的差异中的互补作用
Noushin Sadat Ahanchi1, Farnaz Khatami2, Erand Llanaj3
1Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Bern, Switzerland; Department of Internal Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Clinical nutrition (Edinburgh, Scotland)
|April 9, 2024
概括
铁代谢,而不仅仅是荷尔蒙,可能解释心脏代谢疾病 (CMD) 的性别差异. 绝经后,增加的铁储量与更高的CMD风险相关,这表明铁含量增加.
科学领域:
- 心血管和新陈代谢健康
- 铁的新陈代谢和疾病
- 内分泌学和性别差异
背景情况:
- 荷尔蒙变化是心脏代谢疾病 (CMD) 性别和更年期差异的主要解释.
- 铁代谢在性别和生殖阶段之间存在差异,是CMD发展的一个未被充分研究的因素.
- 新出现的证据将铁与氧化应激和炎症联系起来,这是CMD病变发生的关键途径.
研究的目的:
- 批判性地评估关于CMD的性别和更年期差异的证据.
- 评估雌激素假设作为这些差异的唯一解释的局限性.
- 探索铁代谢作为CMD中补充途径的新兴作用.
主要方法:
- 关于铁代谢,性别差异,更年期和心脏代谢疾病的现有科学文献的综述.
- 分析基础科学发现的铁状况和心脏代谢疾病的发展.
- 对将铁摄入量和生物标志物与2型糖尿病 (T2D) 和心血管疾病 (CVD) 联系起来的流行病学数据的评估.
主要成果:
- 女性在更年期前的铁储量较低,而更年期后的铁储量增加,这与CMD风险增加相吻合.
- 基础科学支持增加铁状况与T2D和心血管疾病 (CVD) 发展之间的联系.
- 血铁,费里丁和转激素和的流行病学证据与T2D风险一致,但对心血管疾病风险有争议.
结论:
- 铁代谢提供了一个潜在的补充性途径,用于解释CMD的性别和更年期差异.
- 流行病学数据的不一致性凸显出需要超越因果推断的观察证据.
- 未来的研究应该集中在评估铁在CMD差异中的作用,以改善理解和临床策略.
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