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介质素-6通过抑制脂肪脂解促进了衰老期间内脏脂肪组织的积累,通过抑制脂肪脂解

Xiaofang Zhang¹, Qingxuan Wang¹, Yaru Wang¹

¹Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China.

International immunopharmacology

|April 9, 2024

概括

介质素-6 (IL-6) 通过抑制脂解,驱动与年龄相关的内脏脂肪积累. 减少IL-6可能会对抗肥胖,并改善老年人的新陈代谢.

科学领域:

老年学是一门学科.
代谢健康代谢健康
炎热性炎热性炎热性

背景情况:

与年龄相关的内脏肥胖与心脏代谢问题有关.
与年龄相关的内脏脂肪增加的机制尚不清楚.
干白素-6 (IL-6) 是一种随着年龄增长而升高的炎症标志物,但其在内脏脂肪中的作用尚不清楚.

研究的目的:

为了研究INTERLEUKIN-6 (IL-6) 在与年龄相关的内脏脂肪组织积累中的作用.
探索IL-6对脂质代谢和衰老过程中的能量消耗的影响.

主要方法:

在老年人 (n=77) 中进行的横截面研究,与IL-6和内脏脂肪相关联.
在具有和没有IL-6 (IL-6 KO) 的老年小鼠中进行验证.
脂肪组织的代谢和组织学分析.

主要成果:

人类血清IL-6和内脏脂肪质量之间存在积极的关联.
年龄较大的小鼠显示IL-6升高,内脏脂肪增加.
在老年小鼠中,IL-6缺乏 (IL-6KO) 减弱了内脏脂肪积累,改善了脂质代谢,增加了能量消耗.
缺少IL-6可减少脂肪细胞缩,并通过PKA促进脂解.

结论:

通过抑制脂解,IL-6在衰老过程中有害地促进内脏脂肪组织的积累.
针对IL-6减少的策略可以减轻与年龄相关的肥胖症并改善代谢健康.

关键词:

衰老的衰老衰老的衰老在IL-6的研究中,IL-6被认为是IL-6的基因.脂质溶解脂质溶解是一种肥胖问题肥胖问题内脏脂肪组织的内脏脂肪

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