一个病例系列的后传染性 chikungunya 骨髓激素单元神经病变
Suresh Selvam1, Padma Youron2, Harpreet Singh1
1Division of Clinical Infectious Diseases, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Journal of the neurological sciences
|April 9, 2024
概括
奇孔古尼亚病毒 (CHIKV) 感染可能导致罕见的神经并发症,如骨髓激核神经病变. 早期使用甲基普雷迪尼索隆的治疗表明,在三名患有这种奇昆古尼亚并发症的患者中,有两名患者有望康复.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 奇孔古尼亚热是一种由蚊子传播的病毒性疾病,由奇孔古尼亚病毒 (CHIKV) 引起.
- 神经系统并发症,虽然很少见,但可以发生在CHIKV感染后.
- 准/后传染性骨髓激素神经病是 chikungunya 的潜在的神经连续病.
研究的目的:
- 报告一系列病例,这些病例中患者在 chikungunya 发烧后经历了骨髓激细胞神经病变.
- 描述这些患者的临床表现,诊断结果和治疗结果.
- 为了突出基孔古尼亚病毒感染后神经系统干预的潜力.
主要方法:
- 审查了三名患有 chikungunya 疾病和随后的神经症状的患者的病例系列.
- 进行了临床检查,脊椎磁共振成像 (MRI) 和神经传导研究.
- 治疗包括甲基prednisolone和,在一个情况下,静脉注射免疫球蛋白.
主要成果:
- 这三名患者都出现了双边下肢虚弱,感官缺陷和肠道干扰后奇昆古尼亚热.
- 神经传导研究表明感应运动轴突多神经病变,而脊柱MRI正常.
- 两名接受甲基普雷迪尼索隆治疗的患者完全康复;一名患者没有改善.
结论:
- 奇孔古尼亚病毒感染可能与准/后传染性骨髓激素神经病变有关.
- 甲基prednisolone似乎是一个有效的治疗这种神经复杂症.
- 需要进一步的研究,以了解病理生理学,并优化治疗 chikungunya 相关的神经疾病.
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