增长差异化因素15和老年人的营养不良
Nazanin Rostami1, Blanca Fabre-Estremera2, Antonio Buño-Soto3
1Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain.
The journal of nutrition, health & aging
|April 9, 2024
概括
高血清生长差异化因子15 (GDF-15) 水平与较差的营养状况和老年妇女营养不良风险增加有关. 在老年男性中没有观察到任何显著的关联,这表明潜在的性别特异性影响.
科学领域:
- 老年学是一门学科.
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 系统性炎症和慢性疾病会提高生长分化因子15 (GDF-15) 的水平.
- 这些情况是已知的致病因素,有助于老年人营养不良.
研究的目的:
- 研究血清GDF-15度与老年人群中营养不良的发展之间的潜在关联.
- 探索GDF-15与营养状况之间的关系中的潜在性别差异.
主要方法:
- 分析了来自老年人-ENRICA-2队列的数据,包括723名女性和735名男性 (≥65岁),平均随访时间为2.2年.
- 营养不良的评估使用了迷你营养评估-简单表格 (MNA-SF);用于分析关联的线性和逻辑回归模型.
- 为关键的潜在混因素进行了调整.
主要成果:
- 在女性中,更高的GDF-15水平与降低的MNA-SF得分和营养不良发病率的增加线性相关.
- 具体来说,GDF-15的25%增加与MNA-SF得分下降0.07个点以及营养不良的可能性增加了1.24倍.
- 在女性中,GDF-15的最高四分位数与较差的营养状况和较高的营养不良风险有显著的关联;在男性中没有发现这种关联.
结论:
- 血清GDF-15度升高与年长女性的营养状况恶化和营养不良风险增加有关.
- 观察到的性别差异需要进一步研究潜在的机制.
- 建议探索GDF-15调制作为预防老年妇女营养不良的治疗策略.
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