选择的多室袋门营养与可纳的兼容性研究
Katarzyna Dettlaff1, Gabriela Anglart1, Agnieszka Gruszczyńska1
1Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Poznań, Poland.
Nutrition (Burbank, Los Angeles County, Calif.)
|April 9, 2024
概括
弗卢可纳 (FLZ) 与六种亲肠道营养 (PN) 配方兼容,证实了重症患者同时服用的安全性. 这样可以确保在一个输液线中安全地在FZ和PN的Y位处方.
科学领域:
- 制药科学 制药科学
- 临床药房 临床药房
- 关键护理医学 关键护理医学
背景情况:
- 可纳 (FLZ) 对于治疗真菌感染至关重要,特别是在免疫力低下,艾滋病毒感染和癌症患者中.
- 危急病患者通常需要同时服用药物和肠外营养 (PN).
- 确保在单一输液线中将FLZ与PN结合在一起的安全性对于患者护理至关重要.
研究的目的:
- 为了评估Fluconazole (FLZ) 与六种不同的多室袋内营养 (PN) 配方的物理化学兼容性.
- 为了确定FLZ是否可以安全地与PN同时通过Y站点连接进行管理.
主要方法:
- FLZ溶液与六种PN配方在临床上相关的比例中结合在一起.
- 测量了视觉评估,pH,度,度,粒子大小 (DLS和光遮蔽) 和泽塔潜力.
- 混合后立即进行分析,并在室温下储存4小时后进行分析.
主要成果:
- 在将FLZ与PN结合后,没有观察到视觉变化.
- 度保持在0.4NTU以下,脂质乳液颗粒大小在300nm以下 (PFAT5 ≤0.02%).
- pH和度变化处于可接受的范围内,而zeta潜力表明稳定的混合物.
结论:
- 可纳 (FLZ) 与经过测试的六种多室袋肠营养 (PN) 配方兼容.
- 这种兼容性支持FLZ和PN通过单一输液线 (Y-site) 的同时使用.
- 这些发现为在临床环境中安全使用这种药物-PN组合提供了证据.
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