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Updated: Jun 28, 2025

Metabolic Labeling of Newly Transcribed RNA for High Resolution Gene Expression Profiling of RNA Synthesis, Processing and Decay in Cell Culture
11:00

Metabolic Labeling of Newly Transcribed RNA for High Resolution Gene Expression Profiling of RNA Synthesis, Processing and Decay in Cell Culture

Published on: August 8, 2013

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在整个mRNA生命周期中对RNA结合蛋白的时间解析分析

Yeon Choi1, Buyeon Um1, Yongwoo Na1

  • 1Center for RNA Research, Institute for Basic Science, Seoul 08826, Republic of Korea; School of Biological Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Molecular cell
|April 9, 2024
PubMed
概括

这项研究揭示了随着时间的推移动态的mRNA-蛋白相互作用,揭示了RNA结合蛋白 (RBPs) 在mRNA处理和出口中的新角色. 这些发现挑战了现有的转录合出口模型,并突出了mRNA生命晚期阶段的压力颗粒蛋白.

关键词:
在 NXF1 的情况下.这是一种RNA结合蛋白.通过RNA互动组捕获进行RNA互动组捕获.这里是TREX复合体.mRNA结合动态的结合动态mRNA生命周期的生命周期核出口mRNA的核出口质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量脉冲追踪标签的标签是应力颗粒的压力颗粒

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