重新审视维生素D缺乏和活跃结核病之间的关联:台湾的一项前性病例控制研究
Meng-Shiuan Hsu1, Tzu-Chien Chung2, Ping-Huai Wang3
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, Section of Infectious Disease, Far Eastern Memorial Hospital, New Taipei, Taiwan.
维生素D缺乏 (VDD) 是发展活跃结核病 (TB) 的重要危险因素. 这项研究发现,VDD独立地增加了结核病风险,强调了未来试验中需要针对性补充的需要.
科学领域:
- 营养免疫学 营养免疫学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 以前对结核病 (TB) 发病率的维生素D补充剂的试验 yielded 非显著的结果.
- 维生素D缺乏症 (VDD) 被定义为血清25(OH) D<20 ng/ml.
- 台湾是一个高收入社会,结核病负担适度,为这项研究提供了相关的环境.
研究的目的:
- 在非艾滋病毒感染者群体中调查VDD与事件性活跃结核病之间的关联.
- 在台湾队列中确定活跃结核病的风险因素.
主要方法:
- 进行了一项前性,年龄/性别匹配的病例控制研究.
- 考虑了包括BMI,吸烟和肝硬化在内的混因素.
- 测量了血清25 (((OH) D水平,以评估VDD.
主要成果:
- 与对照组 (29.8%) 相比,在活跃结核病病例中观察到更高比例的VDD (51.6%).
- 结核病患者的平均25(OH) D水平明显低于对照组 (24.45 ng/ml) 的平均水平 (21.25 ng/ml).
- VDD (aOR:3.03),低BMI,肝硬化和吸烟被确定为活性结核病的独立危险因素.
结论:
- 证实VDD是发生性活性结核病的独立风险因素.
- 未来的维生素D补充试验应针对低BMI或其他已确定的风险因素的个体,以提高统计能力.
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