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Updated: Jun 28, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Published on: December 9, 2015

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超出DHFR放大范围的人类癌症细胞系中对甲醇抗的动态基因组变化表明,预防耐药性的潜在新目标是预防耐药性

Xiang-Ning Meng1,2, Jin-Fa Ma1,2, Yang-He Liu1,2

  • 1Key laboratory of preservation of human genetic resources and disease control in China (Harbin Medical University), Ministry of Education, Harbin, 150081, China.

British journal of cancer
|April 9, 2024
PubMed
概括

癌症中甲甲酸耐药性通过DHFR基因放大在不同的阶段发展. 染色体外DNA (ecDNA) 的形成是关键的驱动因素,FAM151B,MSH3和ZFYVE16也影响了耐药性.

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