功能性便秘的儿童的口腔和肠道微生物群
Monika Kwiatkowska1,2, Marcin Gołębiewski3,4, Marcin Sikora4
1Department of Paediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100, Torun, Poland. monikasobecka5@gmail.com.
Scientific reports
|April 9, 2024
概括
儿科便秘可能源于肠道微生物组失衡. 这项研究发现,特定的便细菌,如克里斯森氏菌的较低水平和较高的坦内瑞氏菌,在患有便秘的儿童中有所不同.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 便秘影响近30%的儿童,影响了儿科实践.
- 胃肠道微生物组的干扰是小儿便秘的潜在原因.
研究的目的:
- 研究患有便秘和没有便秘的儿童之间的口腔和便微生物组的差异.
- 确定与儿童功能性便秘相关的特定微生物种群.
主要方法:
- 这项研究包括91名儿童 (57名有便秘,34名没有).
- 唾液和便的微生物组使用16S rRNA基因扩增序列测序进行了分析.
- 统计分析发现了细菌数量和多样性的差异.
主要成果:
- 功能性便秘与不同的便微生物群组成有关.
- 在患有便秘的儿童中,观察到伯克霍尔代里亚科,克里斯塞拉科和克洛斯特里迪亚科家族的丰度明显较低.
- 在患有便秘的儿童中,发现了更高的Tannerellaceae丰度和更低的罕见属 (例如,Fusicatenibacter,Parabacteroides) 丰度.
- 两组之间在唾液微生物群多样性或组成方面没有发现显著差异.
结论:
- 患有功能性便秘的儿童在便微生物群细菌丰富度中表现出显著的差异.
- 罕见的品种,如克里斯塞拉属r-7,Fusicatenibacter,Parabacteroides,Romboutsia和Subdoligranulum可能会起到对便秘的保护作用.
- 这些发现强调了便微生物组在儿科便秘中的作用,而唾液微生物组似乎不受影响.
相关概念视频
Anatomy of the Intestines
71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K
Assessment of the Rectum and Anus
205
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
205
Drugs for Treatment of Constipation-Predominant IBS
161
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
161
Chronic Bowel Disorders: Introduction
449
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
449
Bacterial Flora of the Large Intestine
435
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
435
Drugs Affecting GI Tract Motility: Other Laxatives
202
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
202


