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辐射诱导性皮肤炎治疗的演变

Deng Guangmei¹, He Weishan¹, Liu Wenya¹

¹Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|April 9, 2024

概括

辐射引起的皮肤损伤 (RISD) 几乎影响所有放射治疗患者. 这项研究审查了25种局部药物,包括天然,各种,非类固醇和皮质类固醇选择,通过调节炎症途径来预防和管理RISD.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
药理学药理学是指药理学的学科.

背景情况:

辐射诱导的皮肤损伤 (RISD) 是放射治疗 (RT) 的常见且显著的副作用.
大约95%接受RT的患者经历了中度至严重的皮肤反应.
目前缺乏急性辐射性皮肤炎 (ARD) 的治疗标准.

研究的目的:

探索和评估25种用于预防和管理RISD的局部药物.
研究这些剂的作用机制,特别是它们在核因子kappa B通路调节中的作用.

主要方法:

对25种针对RISD进行调查的局部药物的系统审查.
将药物分类为天然,各种,局部非类固醇和局部皮质类固醇组.
机制分析,重点关注抗炎性质和氧化应激预防.

主要成果:

该研究确定了25种用于RISD预防和管理的局部药物.
这些药物包括11种天然药物,3种多种药物,9种局部非类固醇药物,2种局部皮质类固醇药物.
许多药物通过调节核因子kappa B通路来起作用,以减少炎症.

结论:

具有抗炎性质的局部药物显示出保护皮肤和帮助RISD患者的组织再生的希望.
了解作用机制,如NF-κB通路调节,对于有效的RISD预防和管理至关重要.
对这些药物的进一步研究可能会导致改善ARD治疗的临床指南.

关键词:

各种各样的代理商.自然的代理人自然的代理人.辐射诱导的皮肤反应辐射疗法辐射疗法局部使用的皮质类固醇.局部非类固醇剂局部非类固醇剂局部治疗局部治疗

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