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血清乳酸是急性胰腺炎患者短期和长期死亡率的指标

Zhao Zeng¹, Rong Huang¹, Hang Lin¹

¹Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, No. 161 Shaoshan South Road, Changsha, 410004, Hunan, China.

Digestive diseases and sciences

|April 9, 2024

概括

血清乳酸水平可以预测急性胰腺炎 (AP) 患者的短期和长期死亡率,这些患者被送往重症监护室 (ICU). 乳酸水平为2.4mmol/L被确定为预测死亡结果的关键值.

科学领域:

关键护理医学关键护理医学
生物标志物生物标志物
预测指标的预测指标

背景情况:

血清乳酸是一种可访问的生物标志物,用于各种疾病的预后.
急性胰腺炎 (AP) 是一种严重的疾病,需要准确的预后工具.
确定AP结果的可靠预测因素对于及时干预至关重要.

研究的目的:

评估血清乳酸对重症监护室 (ICU) 住院急性胰腺炎 (AP) 患者的短期和长期死亡率的预测能力.
确定血清乳酸盐水平与AP中的死亡结果之间的关系.
为了确定血清乳酸在预测AP死亡率中的潜在切断值.

主要方法:

对接受ICU治疗的AP患者的大型数据集 (MIMIC-IV数据库) 的分析.
构建预测模型以评估血清乳酸与30天,180天和1年死亡率的关联.
使用通用添加剂模型可视化血清乳酸和死亡率之间的关系.

主要成果:

该研究包括895名AP患者,30天,180天和1年的死亡率分别为12.63%,16.87%和17.54%.
在所有时间点中,每增加1mmol/L的血清乳酸与死亡率增加有关 (ORs从1.20到1.21).
血清乳酸证明了死亡率的预测值,AUC从0.653到0.688不等,并确定了2.4 mmol/L的切断值.

结论:

血清乳酸作为一个有价值的指标,用于预测短期和长期的AP患者的死亡率进入ICU.
这些发现支持使用血清乳酸作为一种随时可用的预后生物标志物,用于AP的重症监护机构.
血清乳酸水平为2.4 mmol/L可以帮助AP患者的风险分层.

关键词:

在急性胰腺炎中,在重症监护病房的重症监护病房.死亡率死亡率死亡率血清中的乳酸盐

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