一个与cuproptosis相关的基因签名作为甲状腺癌的预后生物标志物,基于转录学
Zirui Guan1, Hongyong Wang2, Mingyan Tian1
1The Second Hospital of Jilin University, Changchun City, 130022, Jilin Province, People's Republic of China.
Biochemical genetics
|April 9, 2024
概括
这项研究确定CDKN2A是影响甲状腺癌 (THCA) 进展的关键cuproptosis相关基因. 较高的CDKN2A表达表明预后较差,并与功能障碍的瘤免疫微环境联系在一起,将其确立为THCA的潜在预后标志物.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 甲状腺癌 (THCA) 是最常见的内分泌瘤,发病率不断增加.
- 推动THCA侵袭性进展的分子机制在很大程度上是未知的.
- 与cuproptosis相关的基因正在成为癌症发展的重要因素.
研究的目的:
- 研究THCA中与cuproptosis相关的基因的预后和生物学意义.
- 评估CDKN2A作为甲状腺癌预后生物标志物的潜力.
- 探索CDKN2A表达和瘤免疫微环境之间的关系.
主要方法:
- 从UCSC XENA获得基因组和临床数据;从FerrDb.获得与cuproptosis相关的基因.
- 差异表达分析和考克斯回归以确定预后标记.
- 对CDKN2A.进行免疫组织化学染色,生存,免疫学,功能和临床分析.
主要成果:
- CDKN2A表达与THCA预后相反相关.
- 较高的CDKN2A水平与晚期瘤阶段 (T,N),更高阶段和残留瘤细胞有关.
- CDKN2A表达显著预测THCA患者的整体存活率 (OS),并与免疫微环境功能障碍有关.
结论:
- 与cuproptosis相关的基因CDKN2A作为甲状腺癌的宝贵预后标志物.
- CDKN2A表达水平可以预测患者的结果,并为治疗策略提供信息.
- 准CDKN2A或调节相关的免疫微环境可能为THCA治疗提供新的途径.
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