重度抑郁症,精神分裂症和双相情感障碍与甲状腺癌的关联:一个双向的双样本门德尔随机研究
Rongliang Qiu1,2, Huihui Lin3, Hongzhan Jiang3
1The School of Clinical Medicine, Fujian Medical University, Fuzhou, 350122, China.
BMC psychiatry
|April 9, 2024
概括
重度抑郁症和精神分裂症会增加甲状腺癌的风险,但双相情感障碍不会. 这项研究使用了门德尔的随机化来探索精神疾病和甲状腺癌之间的因果关系,没有发现反向因果关系.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 在瘤学瘤学.
背景情况:
- 重度抑郁症 (MDD),精神分裂症 (SCZ) 和双相情感障碍 (BD) 是普遍存在的精神疾病.
- 这些疾病与甲状腺癌风险之间的关联具有显著的研究兴趣.
- 了解这些关系对于公共卫生和临床实践至关重要.
研究的目的:
- 调查MDD,SCZ和BD对甲状腺癌风险的潜在因果影响.
- 为了检查精神疾病和甲状腺癌之间的双向因果关系.
- 为潜在的公共卫生和临床影响提供证据.
主要方法:
- 利用大规模的全基因组关联研究总结统计数据用于遗传变异选择.
- 采用了三种门德尔随机化 (MR) 方法:逆方差加权 (IVW),MR-Egger回归和加权中位数估计器 (WME).
- 进行双向MR分析,并进行异质性和多变量测试以确保有效性.
主要成果:
- 发现MDD可能会增加甲状腺癌的风险 (IVW:OR=3.956,P=0.026;WME:OR=5.563,P=0.050).
- 对SCZ的遗传敏感性与增加的甲状腺癌风险相关 (WME:OR=1.599,P=0.043).
- 在BD和甲状腺癌发病率之间没有发现显著的因果关系,反之亦然.
结论:
- MDD和SCZ与增加甲状腺癌风险存在潜在的积极关联.
- 该研究没有确定BD和甲状腺癌之间的因果关系.
- 需要进一步的研究来阐明生物机制和潜在的混因素.
相关概念视频
Bipolar Disorder
67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Depressive Disorders: Etiology
78
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
78
Depression: Overview
242
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
242
Human Genetics
565
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
565
Biological Causes of Schizophrenia
55
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
55
Psychological and Sociocultural Causes of Schizophrenia
84
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
84


