怀孕期间考虑使用贝利马布:随着时间的推移,这是一个更可行的选择
Paloma Vela-Casasempere1,2,3, Rocío Caño Alameda1, Silvia Gómez Sabater1
1Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
Lupus
|April 10, 2024
概括
在患有狼的孕妇中使用贝利穆马布显示出有希望的结果,没有观察到增加严重胎儿损害的风险. 建议进行进一步的研究以确认怀孕期间的安全性.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 系统性红斑狼 (SLE) 在怀孕期间存在风险.
- 关于孕妇狼患者使用贝利马布等生物疗法的安全性和疗效的数据有限.
- 在怀孕期间治疗狼需要仔细考虑母亲和胎儿的结果.
研究的目的:
- 报告贝利穆马布在患有狼的孕妇中的使用情况.
- 审查关于贝利穆马布在怀孕期间使用的现有文献.
- 评估怀孕期间与贝利穆马布治疗相关的孕产妇和胎儿结局.
主要方法:
- 孕妇狼患者的前性观察研究.
- 在MEDLINE和EMBASE数据库中的系统文献搜索.
- 包含的研究和案例报告的描述性分析.
主要成果:
- 贝利马布在6名妇女的8次怀孕中使用,其中有1次流产和7次活产.
- 在对41个怀孕的更广泛的文献综述中,风险包括早产和子宫前,但没有报告任何发育不良.
- 新生儿的结局通常是有利的,Apgar分数正常,尽管一些新生儿出生时体重低,感染风险增加.
结论:
- 贝利马布可能是耐火性狼的孕妇可行的治疗选择.
- 虽然初步的数据令人鼓舞,但进一步的研究是必不可少的,以最终确定贝利穆马布的安全性概况关于胎儿发育.
- 需要长期研究才能充分了解怀孕期间贝利穆马布暴露的影响.
更多相关视频
09:04Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
9.7K
10:35Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
8.3K
相关概念视频
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
126
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
126
Development of Immunocompetence
305
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
305
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
161
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
161
