在接受选择性内镜逆行胆管-胰腺镜检查的患者中使用德克斯梅德托米丁作为普罗波的辅助剂 - - 一项双盲随机对照研究
T Raghavendra Babu1, M R Anil Kumar1, N R Anup1
1Department of Anesthesiology, Jagadguru Shri Shivarathreshwara Academy of Higher Education and Research, Mysuru, Karnataka, India.
Journal of pharmacy & bioallied sciences
|April 10, 2024
概括
在ERCP期间为程序镇静添加德克斯梅德托米丁,显著减少了对额外的propofol剂量的需求. 这种组合在接受ERCP的患者中提供了更好的安全性和镇静质量.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 普罗波是程序性镇静的主要药物.
- 德克斯梅德托米丁是一种α-2激动剂,可能会增强镇静安全性.
- 将德克斯梅德托米丁与普罗波结合使用可以稳定血液动力学,并在ERCP期间改善镇静质量.
研究的目的:
- 评估将德克斯梅德托米丁与普罗波结合用于手术镇静的疗效和安全性.
- 为了在ERCP期间比较德克斯梅托米丁-普罗波与单独的普罗波的镇静作用和血液动力稳定性.
主要方法:
- 接受ERCP的80名患者被随机分为两个组:德克斯梅托米丁+普罗波 (DP) 和单独的普罗波 (P).
- 组DP接受了德克塞梅托米丁加重剂量,其次是普罗波,而组P仅接受了普罗波.
- 评估了镇静质量,血液动力学参数,呼吸功能和术后恢复得分.
主要成果:
- 与P组 (8.78 ± 1.11) (P=0.001) 相比,DP组需要的救援醇剂量显著减少 (3.47 ± 0.77).
- 在DP组 (316.59±43.29毫克) 与P组 (443±41.1毫克) (P=0.001) 中,普罗波总剂量明显较低.
- 组DP在整个过程中显示出血动力稳定性的统计学显著改善 (P<0.05).
结论:
- 德克斯梅德托米丁和普罗波的组合在ERCP期间提供了优越的镇静作用.
- 这种组合通过保持稳定的血液动力学和降低醇需求来提高程序安全性.
- 德克斯梅德托米丁-普罗波是ERCP程序镇静的有效和安全替代品.
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