单剂量普雷加巴林在手术前儿科镇静中的有效性和安全性
Wafiya Mahdy1, Khaled Saad2, Eman F Gad2
1Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Journal of pharmacy & bioallied sciences
|April 10, 2024
概括
单次口服普雷加巴林剂量有效降低了儿科手术患者的手术前焦虑,并提供镇静. 这种抗焦虑和镇静作用在没有增加不良事件的情况下实现.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术前的焦虑和镇静是儿科手术中的关键考虑因素.
- 需要有效的抗焦虑和镇静剂来改善患者的治疗结果.
- 普雷加巴林是一种具有已知的抗焦虑特性的药物.
研究的目的:
- 在接受选择性手术的儿科患者中研究单剂口服普雷加巴林 (5毫克/千克) 的抗焦虑和镇静作用.
- 评估普雷加巴林对双光谱指数 (BIS) 反应的影响.
- 为了评估普雷加巴林在这个人群中的潜在不良影响.
主要方法:
- 潜在的随机临床试验涉及60名儿科患者.
- 在麻醉诱导前一个小时随机分配给口服普雷加巴林 (5毫克/千克) 或安慰剂.
- 使用视觉模拟焦虑量表 (VAS-A) 评估焦虑,使用兰赛镇静量表 (RSS) 评估镇静.
主要成果:
- 与安慰剂相比,普雷加巴林显著降低了手术前的焦虑 (较低的VAS-A分数).
- 在pregabalin组中观察到显著更高的镇静水平 (RSS).
- 在普雷加巴林组中,在输管,皮肤切口和恢复过程中注意到了较低双谱指数 (BIS) 的反应.
结论:
- 单次手术前剂量的普雷加巴林有效降低了儿科手术患者的焦虑.
- 普雷加巴林可以达到镇静状态,而不会显著增加不良反应.
- 普雷加巴林在儿科手术中显示出作为安全有效的前期治疗的潜力.
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