从通过乳液交叉连接制备的单分散基托微球中控制输送5-甲
Tong Wan1, Qianqian Zhang1, Guocheng Jin2
1School of Materials Science and Engineering, East China University of Science and Technology Shanghai 200237 China saxu@ecust.edu.cn.
RSC advances
|April 10, 2024
概括
研究人员优化了酸盐微球,以提供5-甲 (5-FU). 这些pH响应的微球提供受控释放,显示了改善癌症治疗的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 酸盐 (CHS) 是一种多功能生物聚合物,在制药应用中具有显著的潜力.
- 开发有效的药物输送系统对于改善治疗结果至关重要.
- 微球为控制和向药物释放提供了优势.
研究的目的:
- 优化乳液交叉连接条件,以生产带有5-甲的奇托桑微球 (5-FU/CHS).
- 描述合成的微球的物理化学特性和药物载荷.
- 评估5-FU/CHS微球的体外药物释放特征和动力学.
主要方法:
- 基托与甲的乳液交叉连接.
- 合成含有5-甲的奇托桑微球 (5-FU/CHS).
- 使用动态光散射,扫描电子显微镜,热重力测量分析,X射线衍射和里埃变换红外光谱学进行表征.
- 在不同的pH条件下进行体外药物释放研究和运动分析.
主要成果:
- 确定了乳液交叉链接的最佳条件.
- 5-FU/CHS微球显示药物负载 (3.87-12.35%) 和封装效率 (20.13-70.45%).
- 微球是球形的,尺寸为微米,分布均,并证实了5-FU的成功结合.
- 在酸性条件下,经过长时间的,响应pH的5-FU释放,在酸性条件下显著增加.
- 药物释放遵循了Fickian扩散模型.
结论:
- 优化的基托桑微球是5-甲的有效载体.
- 响应pH的释放特征表明有针对性的癌症治疗的潜力.
- 菲克斯扩散模型为释放机制提供了洞察力,有助于进一步发展.
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