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Updated: Jun 28, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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通过群体的药理动力学和药理动力学研究,优化Rituximab用于原发性膜性病的剂量

Hao Liang1,2, Zhenling Deng1, Shu Niu2

  • 1Department of Nephrology, Peking University Third Hospital, Beijing, China.

Frontiers in pharmacology
|April 10, 2024
PubMed
概括

这项研究开发了第一个人群药理动力学和药理动力学 (PPK/PD) 模型,用于原发性膜性病 (PMN) 中的利图西马布. 该模型支持一种新的低剂量疗法,有效地减少B细胞,降低风险和成本.

关键词:
优化剂量优化剂量优化人口的药理动力学和药理动力学.原发性膜性脏病 - 一次性膜性脏病.这就是Rituximab.目标介导的药物处置是指通过目标介导的药物处置.

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