开发和外部验证用于预测非子宫内膜癌患者的整体存活率的诺姆图:基于人口的分析
Jingya Chen1, Xiaorong Wang2, Qinfeng Xu1
1Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Heliyon
|April 10, 2024
概括
这项研究开发了一种名谱,用于预测非子宫内膜腺癌患者的生存率. 该工具有效预测了3年和5年生存率,有助于临床决策.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 非子宫内膜腺癌 (NEEC) 是一种罕见的亚型,具有明显的预后因素.
- 准确预测整体存活率对于有效的患者管理和治疗计划至关重要.
研究的目的:
- 确定NEEC患者整体生存的关键预测因素.
- 开发和验证一个用于预测NEEC中3年和5年的总生存率的诺姆图.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库 (1988-2018) 中对2686名NEEC患者的回顾性分析.
- 患者被分为培训,内部验证和外部验证队列 (来自中国的41名患者).
- 考克斯回归分析确定了独立的风险因素;构建并验证了一个名图.
主要成果:
- 确定了整体存活时间的八个独立预测因素.
- 诺米图表显示出良好的预测性能,C指数为0.734 (训练),0.700 (内部验证) 和0.767 (外部验证).
- 校准图表和决策曲线分析证实了名图的临床实用性.
结论:
- 一个经过验证的nomogram成功构建用于预测NEEC患者的整体存活率.
- 这种工具可以帮助临床医生预测3年和5年生存结果.
- 诺米图表是个性化风险评估和NEEC临床决策的有效工具.
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