在接受选择性PCI的患者中,手术后心脏托波宁I的升高和与5年死亡率的关联
Queyun Sun1, Pei Zhu1, Jingjing Xu1
1Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, A 167 Beilishi Road, Xicheng District, Beijing, 100037, China.
术后心脏托波宁I水平是上限的70倍,可独立预测选择性穿皮冠状动脉干预后5年死亡率. 这个由SCAI 2014定义的值对于评估这些患者的长期预后至关重要.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 干预心脏病学 干预心脏病学
背景情况:
- 皮肤穿刺冠状动脉干预 (PCI) 后心脏热素I (cTnI) 值的预后意义仍在争论中.
- 确定临床上有意义的cTnI值对于长期患者的治疗结果至关重要.
研究的目的:
- 评估各种手术后cTnI水平与5年死亡率之间的关联.
- 确定一个特定的cTnI值,预测可选PCI后的长期预后.
主要方法:
- 对4059名基线正常cTnI患者进行选择性PCI的分析.
- 在PCI后8-48小时内测量手术后的cTnI水平.
- 评估作为主要终点的五年全因和心血管死亡率.
主要成果:
- 术后的cTnI ≥70倍以上的上限 (URL) 独立预测了5年全因和心血管死亡率.
- 较高的cTnI峰值水平与较高的死亡率相关.
- 心血管血管图谱与干预学会 (SCAI) 的2014年值 (≥70xURL) 显示与死亡率有显著的关联.
结论:
- 在接受选择性PCI的患者中,术后cTnI水平≥70xURL是5年死亡率的独立预测因素.
- 2014年SCAI cTnI值是评估这一群体的长期死亡风险最相关的.
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