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传统中医治疗特异性膜性病:一个系统性审查和元分析

Wenjun Shan¹, Haiyu Guan¹, Haowen Gu¹

¹State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.

|April 10, 2024

概括

传统中医 (TCM) 在治疗异形膜性病 (IMN) 方面表现有前途,改善缓解率并减少与单独西医相比的不良影响. 需要进一步进行高质量的试验,以确认其在IMN管理中的有效性.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
自免疫性疾病自免疫性疾病
综合医学是一个整体的医学.

背景情况:

异形膜性病 (IMN) 是一种罕见的自身免疫性病,在成年人中引起性综合征.
目前用于IMN的免疫抑制疗法具有有限的疗效和显著的不良影响.
传统中医 (TCM) 为IMN管理提供了一个潜在的替代方案.

研究的目的:

系统地评估TCM的安全性和有效性,单独或与西方医学结合,用于治疗IMN.
评估TCM对IMN患者的缓解率,蛋白尿和关键生物标志物的影响.

主要方法:

来自英语和中文数据库的随机对照试验 (RCT) 的系统审查.
包括1982名IMN患者的29个RCT.
使用RevMan软件进行偏差风险评估和元分析.

主要成果:

与单独使用西方医学相比,TCM (单独或组合) 显著改善了总,完全和部分缓解率.
经过TCM治疗,血清白蛋白水平得到改善,蛋白尿,血清肌和抗PLA2R抗体水平降低.
综合的TCM和西方医学在减少感染,肝毒性和血栓发生率方面表现出卓越的疗效.

结论:

单独或与西方医学一起使用TCM似乎是IMN的可行的治疗选择.
中等质量的证据表明TCM有好处,但需要高质量,广泛的临床试验才能得出最终的结论.

关键词:

异常发病的膜性脏病.进行元分析分析.系统性审查系统性审查传统的中国医学是传统的中国医学.

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