产前分娩风险的母胎神经发育基础早产风险
Cesare Miglioli1, Matteo Canini2, Edoardo Vignotto1
1Research Center for Statistics, University of Geneva, Boulevard Du Pont-d'Arve 40, 1205 Geneva, Switzerland.
Heliyon
|April 10, 2024
概括
胎儿大脑连接的差异预测了早产风险. 将大脑数据与孕产妇因素相结合,可以提高预测能力,提供有关出生前神经发育风险的见解.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 改变神经发育是早产 (PTB) 的重要并发症,子宫内因素在很大程度上尚未被探索.
- 研究胎儿大脑的功能连接提供了一个新的窗口来了解PTB对神经发育的影响.
研究的目的:
- 检查胎儿大脑功能连接和早产风险之间的关系.
- 评估是否结合胎儿大脑数据可以改善PTB风险的预测模型.
主要方法:
- 在31个怀孕中使用休息状态功能磁共振成像 (rs-fMRI),按PTB风险分层 (低与高).
- 应用贪等价性搜索 (GES) 用于连接性分析和蒙特卡洛排列测试进行群组比较.
- 为预测PTB风险,开发并比较带有和没有胎儿大脑连接数据的随机森林模型.
主要成果:
- 与低风险怀孕相比,高风险PTB怀孕的胎儿大脑功能连接减少.
- 结合胎儿大脑连接的模型 (MaFra-Neuro) 证明了改善PTB风险预测的准确性.
- MaFra-Neuro类概率与出生时的妊娠年龄,PTB风险梯度和围产期临床条件有显著的相关性.
结论:
- 胎儿大脑的功能连接是PTB的一个有希望的,尚未探索的预测因素.
- 这种连接与母亲的风险概况有关,并预测出生的神经发育风险.
- 研究结果表明,胎儿大脑连接可以弥合不同的PTB表型及其长期后果.
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