晚期发作的严重肌痛性肌痛症的临床特征
Chenjing Sun1, Zhuangzhuang Ren2, Xiuling Miao1
1Senior Department of Neurology, The First Medical Center of PLA General Hospital, Beijing, China.
Heliyon
|April 10, 2024
概括
晚期发作的肌痛性肌痛症 (LOMG) 主要影响女性,并经常呈现出死. 像面部神经Jolly测试这样的诊断测试在IIb类LOMG患者中最有效.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 晚发性肌痛性肌痛症 (LOMG) 由于并发症和非特异性初始症状,存在诊断方面的挑战.
- 关于LOMG的临床特征的有限的大规模调查存在.
- 准确的LOMG诊断对于有效的患者管理至关重要.
研究的目的:
- 总结LOMG的临床特征.
- 为了提高老年人肌痛性骨髓灰质炎 (MG) 的诊断率.
- 在LOMG中确定关键的临床特征和诊断模式.
主要方法:
- 进行了一项回顾性队列研究.
- 包括240名65岁及以上的LOMG患者.
- 从2003年1月1日至2023年1月1日期间接受治疗的患者收集了数据.
主要成果:
- 男性与女性的比例为1:1:2.
- 大多数患者接受了MGFA I类 (31.3%) 和II类 (IIa 12.9%,IIb 51.3%) 的治疗.
- 症 (78.8%) 是最常见的发病症状,其次是双眼视 (18.8%).
- 吞功能障碍发生在41.7%的患者中.
- 胸腺瘤发生率为14.2%.
- 在85.4%的患者中检测到乙胆受体 (AChR) 抗体.
- 总体上,对高最大级重复神经刺激 (乔利测试) 的阳性率为57.1%,其中面部神经的阳性率最高 (50.7%).
- 快乐测试显示了IIb类中最高的阳性率和I类中最低的阳性率 (P=0.030).
结论:
- LOMG发病率显示没有显著的性别差异.
- 临床表现主要是轻度至中度 (I和II类),严重病例罕见.
- 症是最常见的初始症状.
- 在LOMG中,胸腺瘤的发病率很低.
- 面部神经Jolly测试对于LOMG检测非常敏感.
- 根据临床分类,Jolly测试的诊断产量有所不同,在IIb类中最高.
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