在COPD患者中,ADO指数可以作为COVID-19死亡率的预测指标吗?
Esra Ertan Yazar1, Gulsah Gunluoglu2, Burcu Arpinar Yigitbas1
1Department of Chest Diseases, Istanbul Medeniyet University, Medical Faculty, Istanbul, Turkey.
概括
ADO指数是COPD患者的标记,可以预测COVID-19死亡率. 较低的乙氨基酸细胞数量和较高的ADO指数得分表明这些患者的死亡风险增加.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 慢性阻塞性肺病 (COPD) 患者面临COVID-19死亡的高风险.
- 关于COVID-19患者COPD死亡率的预测因素的证据有限.
研究的目的:
- 确定用于预测COVID-19患者诊断为COPD的死亡率的有用标志物.
- 在这个患者群体中研究ADO指数的预测值.
主要方法:
- 一项国家多中心观察性研究 (COPET) 包括689名经螺旋计确认的COPD患者.
- 患者被追溯分析了COVID-19诊断和结果.
主要成果:
- 105名患者有PCR阳性COVID-19;有19人死亡.
- 在非幸存者中观察到更高的身体质量指数和ADO指数,更低的预测FEV1和乙氨基酸细胞计数.
- 每个ADO指数 (年龄,呼吸不良,气流阻塞) 的单位增加,死亡风险增加了2.12倍;每一个乙酸细胞数量的单位增加,风险降低了1.007倍.
- 一个ADO分数为3.5的预测死亡率与94%的灵敏度.
结论:
- 在稳定的COPD期间评估的ADO指数,为COVID-19死亡率提供了适度的预测值.
- 需要进一步的研究来验证ADO指数用于预测COVID-19和其他COPD患者呼吸道病毒感染中的死亡率.
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